Next-generation allogeneic cell therapies

 

Off-the-shelf CAR-T cell therapies for hematologic indications

CB-010

     

Armoring: checkpoint disruption
Target: CD19
Editing: PD-1 KO
Indications: r/r B-NHL
FDA Designations: Regenerative Medicine Advanced Therapy (RMAT)
Fast Track
Orphan Drug

CB-010 is our lead clinical-stage program and is an allogeneic anti-CD19 CAR-T cell therapy for the treatment of patients with relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL). CB-010 is the first allogeneic CAR-T cell therapy, to our knowledge, in a clinical trial with a PD-1 knockout, a genome-editing strategy designed to improve antitumor activity by limiting premature CAR-T cell exhaustion. We use Cas9 chRDNA guides to make three edits to manufacture CB-010: 1) we knock out the TRAC gene to remove the T cell receptor, 2) we site-specifically insert an anti-CD19 CAR into the TRAC gene, and 3) we knock out PD-1. CB-010 is being evaluated in the ongoing, open-label, multicenter ANTLER  Phase 1 clinical trial in adults with r/r B-NHL.

CB-011

     

Armoring: immune cloaking
Target: BCMA
Editing: B2M KO, B2M–HLA-E insertion
Indications: r/r MM
FDA DESIGNATIONS:
Fast Track
Orphan Drug

CB-011 is our second clinical-stage program and is an allogeneic anti-BCMA CAR-T cell therapy for the treatment of patients with relapsed or refractory multiple myeloma (r/r MM). We use the Cas12a chRDNA genome-editing technology to make four edits in the manufacture of CB-011: 1) we knock out the TRAC gene to remove the T cell receptor; 2) we site-specifically insert a humanized anti-BCMA CAR into the TRAC gene; and 3) we site-specifically insert a gene encoding a B2M–HLA-E-peptide fusion into the B2M gene, 4) which knocks out the endogenous B2M gene. This method simultaneously eliminates endogenous HLA class I presentation on the surface of the CAR-T cells and expresses HLA-E, a minor HLA class I antigen, to blunt both T and NK cell-mediated rejection of the CAR-T cell therapy by the patient’s immune system. CB-011 is being evaluated in the open-label, multicenter CaMMouflage Phase 1 clinical trial in adults with r/r MM.

CB-012

     

Armoring: checkpoint disruption and immune cloaking
Target: CLL-1
Editing: PD-1 KO, B2M KO, B2M–HLA-E insertion
Indications: r/r AML

CB-012 is our third program and is an allogeneic anti-CLL-1 CAR-T cell therapy for the treatment of relapsed or refractory acute myeloid leukemia (r/r AML). CLL-1 (also known as CD371) is expressed on the surface of AML tumor cells and leukemic stem cells, but it is not expressed on normal hematopoietic stem cells, which makes it a compelling target for the treatment of AML. We use the Cas12a chRDNA genome-editing technology to make five edits in the manufacture of CB-012: 1) we knock out the TRAC gene to remove the T cell receptor; 2) we site-specifically insert a human anti-CLL-1 CAR into the TRAC gene; 3) we knock out PD-1; and 4) we site-specifically insert a gene encoding a B2M–HLA-E-peptide fusion into the B2M gene, 5) which knocks out the endogenous B2M gene. CB-012 is being evaluated in the ongoing, open-label, multicenter AMpLify Phase 1 trial.

Clinical trials

We have three ongoing, open-label, multicenter, Phase 1 clinical trials.

ANTLER Phase 1 trial for CB-010 in patients with relapsed or refractory B cell non-Hodgkin lymphoma

ANTLER clinical trial

CaMMouflage Phase 1 trial for CB-011 in patients with relapsed or refractory multiple myeloma

CaMMouflage clinical trial

AMpLify Phase 1 for CB-012 in patients with relapsed or refractory acute myeloid leukemia

AMpLify clinical trial

Expanded access to investigational medicines

At Caribou, we are committed to developing transformative genome-edited allogeneic, or off-the-shelf, cell therapies, including chimeric antigen receptor T (CAR-T) cell therapies for hematologic malignancies. These investigational therapies have not yet been approved by regulatory authorities, such as the U.S. Food and Drug Administration (FDA). We are focused on conducting the clinical trials necessary to apply for regulatory approvals to make our allogeneic cell therapies broadly available to patients.

“Expanded access” refers to the use of an investigational therapy outside of a clinical trial for the potential treatment of a serious or immediately life-threatening condition. At this time, Caribou does not have active expanded access protocols nor does it currently provide access to its investigational therapies on an expanded access basis.

We believe the best way to develop therapies that may provide benefits for the largest number of patients is to conduct rigorous clinical development programs. Participation in one of our clinical trials is the best and preferred route to access these investigational products. Patients and physicians interested in Caribou’s investigational therapies are encouraged to learn more about the company’s ongoing clinical trials by visiting the clinical trials section of the Caribou website or clinicaltrials.gov and searching for Caribou Biosciences.

Physicians with questions about participating in one of Caribou’s clinical trials can submit a request to clinicaltrials@cariboubio.com.

Caribou will acknowledge receipt of requests and respond to inquiries within approximately 5 business days.

Caribou Biosciences periodically reviews its policies to ensure conformity with applicable laws and regulations and reserves the right to revise this position at any time.